Best Lubricant for Dry Vagina: Comfort & Relief Naturally Zeelab Pharmacy Moisturisers vs lubricantswhat's the difference for comfort? The Womens Health Clinic Vaginal Lubrication: Vaginal Dryness, Vaginal Health, and More Katie Couric Media contributor and OB GYN Dr. Mary Claire Haver says patients often ask if they should use a vaginal moisturizer or a lubricant and there's a big difference.